The THOR Effect: Thyroid Hormone Offsets Retinopathy

Mechanism of Action of the Thyroid Hormone on the Heart

SUMMARY  The foliowing cardiac effects may be at­tributed to thyroxin:  1-Thyroxin augments all anaerobic pro­cesses in the body includ::ng the heart, and decreases the glycogen content of the heart ( 1, 2, 5, 27). The resistance of the heart to anoxia is increased in hyperthyroidism ( 25). 2- Thyroxin influences the cardiac weight and prevents cardiac atrophy (3, 8, 10, 11, 19, 20, 21, 30...

Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context

Objective: Diabetes mellitus (DM) is known as the silent pandemic. It is hypothesized that other endocrine systems are affected by the metabolic changes occurring due to DM. We aimed to investigate the correlation of thyroid hormones with glycaemic and lipid parameters. Materials and Methods: 81 diabetic patients and 81 non-diabetic age and sex-matched healthy volunteers participated in the st...

Thyroid Stimulating Hormone Thyroid Stimulating Hormone

Thyroid Hormone Response Element Half-Site Organization and Its Effect on Thyroid Hormone Mediated Transcription

Thyroid hormone (TH) exerts its effects by binding to the thyroid hormone receptor (TR), which binds to TH response elements (TREs) to regulate target gene expression. We investigated the relative ability of liganded homodimers TR and retinoid X receptor (RXR), and the heterodimer TR/RXR, to regulate gene expression for the TRE half-site organizations: direct repeat 4 (DR4), inverted repeat 0 (...

The thermogenic effect of thyroid hormone and its clinical implications.

Clinicians are very familiar with cold or heat intolerance in patients with altered thyroid function. While nonspecific, these symptoms have some predictive value in the diagnosis of thyroid dysfunction. Involuntary changes in weight are also perceived as indicators of abnormal thyroid function, often prompting laboratory testing of thyroid gland function. Most of the clinical manifestations of...